2-{[(4-Methoxyphenyl)dimethylsilyl]methyl}isoindoline-1,3-dione
نویسندگان
چکیده
In the course of our studies of silicon-containing anti-cancer compounds, the title compound, C(18)H(19)NO(3)Si, was synthesized. The mol-ecular geometry including bond distances and angles involving the Si atoms are typical. Torsion angles associated with the isoindoline ring and the silyl group [C-N-C(methyl-ene)-Si = 90.5 (2) and -93.1 (2)°] indicate that there is no inter-action between the O and Si atoms despite silicon's high affinity for oxygen.
منابع مشابه
5,6-Dichloro-2-(3-methoxyphenyl)isoindoline-1,3-dione
The title compound, C(15)H(9)Cl(2)NO(3), crystallizes as an inversion twin, the ratio of the twin components being 0.43 (13):0.57 (13). The isoindoline group is planar and inclined by 77.63 (3)° to the aromatic ring substituent. The crystal structure is stabilized by aromatic π-π stacking inter-actions involving the benzene rings of adjacent isoindoline groups, with a centroid-centroid distance...
متن کامل2-(2-Fluoro-4-hydroxybenzyl)isoindoline-1,3-dione
In the title compound, C(15)H(10)FNO(3), the dihedral angle between the isoindoline-1,3-dione and 3-fluoro-4-methyl-phenol groups is 86.88 (8)°. The isoindoline-1,3-dione fragment is almost planar, with an r.m.s. deviation of 0.0154 Å within the group. Inter-molecular C-H⋯O hydrogen bonds generate C(6) chains running parallel to the [010] direction.
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A green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side produ...
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A green and convenient protocol is described for the preparation of 1-(alkylamino)-3-(1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl benzoates via one-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an aromatic carboxylic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there...
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In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8 (1) and 6.6 (1)° with the isoindole-1,3-dione mean plane. The cyclo-hexane ring adopts a chair conformation.
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عنوان ژورنال:
دوره 66 شماره
صفحات -
تاریخ انتشار 2009